Comparative safety of antiepileptic drugs during pregnancy
نویسندگان
چکیده
منابع مشابه
Comparative safety of antiepileptic drugs during pregnancy.
OBJECTIVE To assess the safety of the newer antiepileptic drugs (AEDs) during pregnancy. METHODS The study population was pregnant women who enrolled in the North American AED Pregnancy Registry between 1997 and 2011. Data on AED use and maternal characteristics were collected through phone interviews at enrollment, at 7 months' gestation, and postpartum. Malformations were confirmed by medic...
متن کاملAre newer antiepileptic drugs associated with improved safety in pregnancy compared to older antiepileptic drugs?
Commentary As a group, antiepileptic drugs (AEDs) are associated with an increased risk of major congenital malformations (MCMs) (1). Older AEDs are the best studied. Valproate (VPA) is consistently associated with an increased risk of MCMs including an increased risk of spina bifida (2). Phenobarbital (PB) exposure increases the risk of MCMs, including oral clefts (3). Although not consistent ...
متن کاملNeurological teratogenic effects of antiepileptic drugs during pregnancy
Epilepsy is one of the few neurologic disorders that requires a constant treatment during pregnancy. Epilepsy affects 0.3-0.8% of pregnant women. Prescription of antiepileptic drugs (AEDs) to pregnant women with epilepsy requires monitoring and maintaining a balance between limiting seizures and decreasing fetal exposure to the potential teratogenic effects. AEDs are also commonly used for psyc...
متن کاملSafety of the newer antiepileptic drug oxcarbazepine during pregnancy.
OBJECTIVE Seizure control in pregnant women with epilepsy is vital, as maternal seizures may have deleterious consequences. The treatment of pregnant women with epilepsy is, however, complicated by the teratogenicity of older antiepileptic drugs (AEDs). In this review, the safety of the newer AED oxcarbazepine during pregnancy is assessed based on published pregnancy outcome data. Other relevan...
متن کاملREVIEW Antiepileptic drugs: safety in numbers?
Epilepsy is a common neurological condition, with a lifetime prevalence of between 2%1, 2 and 5%3 of the general population, and a point prevalence of between 4 and 80 per 10004. So common is it among all races that epilepsy may be viewed, not as a rare curse on the individual, but as an all-too frequent price that man and other vertebrates pay for maintaining a plastic and adaptable central ne...
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ژورنال
عنوان ژورنال: Neurology
سال: 2013
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.0b013e3182858ba3